Resting-state Abnormalities in Heroin-dependent Individuals

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Gray matter deficits and resting-state abnormalities in abstinent heroin-dependent individuals.

Previous neuroimaging studies have demonstrated both structural and functional damages in heroin-dependent individuals. However, few studies investigated gray matter deficits and abnormal resting-state networks together in heroin-dependent individuals. In the present study, voxel-based morphometry (VBM) was used to identify brain regions with gray matter density reduction. Resting-state fMRI co...

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Previous functional imaging studies on heroin addicts have focused on abnormal brain functions based on specific tasks, while few fMRI studies concentrated on the resting-state abnormalities of heroin-dependent individuals. In the current study, we applied the pattern classification technique, which employs the feature extraction method of non-negative matrix factorization (NMF) and a support v...

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Altered Fronto-Striatal and Fronto-Cerebellar Circuits in Heroin-Dependent Individuals: A Resting-State fMRI Study

BACKGROUND The formation of compulsive pattern of drug use is related to abnormal regional neural activity and functional reorganization in the heroin addicts' brain, but the relationship between heroin-use-induced disrupted local neural activity and its functional organization pattern in resting-state is unknown. METHODOLOGY/PRINCIPAL FINDINGS With fMRI data acquired during resting state fro...

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Combining spatial and temporal information to explore resting-state networks changes in abstinent heroin-dependent individuals.

Majority of previous heroin fMRI studies focused on abnormal brain function in heroin-dependent individuals. However, few fMRI studies focused on the resting-state abnormalities in heroin-dependent individuals and assessed the relationship between the resting-state functional connectivity changes and duration of heroin use. In the present study, discrete cosine transform (DCT) was employed to e...

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Heroin maintenance for chronic heroin-dependent individuals.

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ژورنال

عنوان ژورنال: Neuroscience

سال: 2018

ISSN: 0306-4522

DOI: 10.1016/j.neuroscience.2016.11.018